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Causes of Appendiceal Cancer

Delve into the little-understood causes of appendiceal cancer, a rare but important condition affecting the appendix.

  • 16 Oct 2023
  • 3 min read

Appendiceal cancer is a rare type of cancer that starts in the appendix, a small tube attached to your large intestine. The causes of appendiceal cancer are still mostly unknown. Several factors, including age, gender, particular medical conditions, and genetic factors like a family history of certain disorders, have been linked to an increased chance of this cellular failure, even if the causes of appendiceal cancer are unknown. In this article, we’ll explore the causes and risk factors of this condition.


How is Appendiceal Cancer Caused?

The exact causes of appendiceal cancer are not well understood, and there are no identified avoidable risk factors. Several factors have been observed in association with this condition, including:

  1. Pernicious Anaemia:
  • It has been studied that vitamin B12 deficiency, which causes pernicious anaemia, could be a risk factor.
  1. Atrophic Gastritis:
  • It has been proposed that this long-lasting stomach lining inflammation, also known as atrophic gastritis, may be one of the appendiceal cancer causes.
  • The development of cancer may be influenced by persistent inflammation.
  1. Zollinger-Ellison Syndrome:
  • An increased risk of appendix cancer has been linked to Zollinger-Ellison syndrome, a rare digestive tract condition characterised by excessive production of stomach acid.
  1. Family history of MEN1:
  • People who have a family history of MEN1, a genetic condition that predisposes people to cancers in hormone-producing glands, may be more likely to develop appendiceal cancer.
  1. Smoking:
  • It has been proposed that smoking might be a potential appendix cancer cause.
  • The appendix could potentially develop malignant alterations as a result of the toxins found in cigarette smoke.

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For individuals with early-stage appendix cancer, the prognosis is usually favourable, with a good chance of recovery. The causes of appendiceal cancer often go unnoticed until it is discovered during surgery for unrelated issues. This underscores the importance of regular medical check-ups. Following a cancer diagnosis, regular follow-up appointments with your healthcare practitioner are essential to monitor for any potential cancer recurrence. Also, ensure that you have a health insurance plan in place to safeguard yourself against any financial stress.


Disclaimer: the above blog aims to provide general information about health and related topics. Any information provided in this blog, website or in any linked materials is not intended and should not be considered, or used as a substitute for any medical advice, diagnosis or treatment. It is important that you contact your doctor before starting a new medicine or health regime.

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