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Causes of Lupus Nephritis

Explore the underlying causes of lupus nephritis, a severe kidney complication linked to systemic lupus erythematosus (SLE).

  • 17 Oct 2023
  • 3 min read

Lupus nephritis is a kidney condition that is frequently linked to the autoimmune disorder systemic lupus erythematosus. The immune system incorrectly targets healthy kidney tissues in lupus nephritis, resulting in inflammation and damage. If left untreated, this can result in oedema, high blood pressure, and even renal failure. It can also cause the kidneys to be less effective at filtering waste and extra fluid from circulation. In this section, the primary attention is placed on the causes of lupus nephritis, which results from the autoimmune character of SLE, causing kidney involvement and associated functional impairment. For patients with lupus nephritis, early detection and effective therapy are essential to preventing kidney damage and maintaining general health.


How is Lupus Nephritis Caused?

The primary cause of lupus nephritis is systemic lupus erythematosus (SLE), an autoimmune condition in which the immune system targets healthy tissues like the kidneys. Here is how it functions:


  1. Immunological Reaction
  • SLE triggers a hyperactive immune system which is a major cause of lupus nephritis.
  • Various bodily tissues accidentally get attacked by immune system proteins (antibodies).


  1. Involvement of the Kidneys
  • The kidneys accumulate immune complexes, which are made up of antigens and antibodies.
  • As a result, the kidneys become inflamed and suffer tissue damage.


  1. Deficient Filtration
  • Kidneys become less efficient in removing waste and extra fluid.
  • The body begins to accumulate wastes and toxins.


  1. Deterioration of Kidney Function
  • The functioning of the kidneys may deteriorate over time as a result of persistent injury.
  • Kidney failure and high blood pressure are examples of potential consequences.


  1. Environmental and Genetic Influences
  • Susceptibility may depend in part on genetics.
  • Environmental factors can play a role, including illnesses and specific drugs.

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In conclusion, lupus nephritis develops from SLE, an autoimmune condition in which the immune system damages the kidneys accidentally. If left untreated, this may result in significant kidney issues, such as renal failure. To manage the illness and maintain general health, early detection and appropriate treatment are essential. It is crucial to continue research in finding the root causes of lupus nephritis. For those facing lupus nephritis, understanding and improved treatments offer hope for better days ahead. Also, ensure that you have a health insurance plan in place to safeguard yourself against any financial stress.


Disclaimer: the above blog aims to provide general information about health and related topics. Any information provided in this blog, website or in any linked materials is not intended and should not be considered, or used as a substitute for any medical advice, diagnosis or treatment. It is important that you contact your doctor before starting a new medicine or health regime.

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