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Causes of Peripheral Artery Disease

Gain a comprehensive understanding of PAD's etiology, unraveling the multifaceted factors contributing to the development of this prevalent vascular condition.

  • 12 Jan 2024
  • 3 min read

Peripheral artery disease, or PAD, is a disorder that impacts the blood vessels that supply the lower limbs and is characterised by blood flow restriction caused by constricted arteries. This disorder develops because of plaque buildup in the arteries, which limits blood flow. In this article, we’ll discuss peripheral vascular disease’s etiology, to better understand the condition.


What are the Causes of Peripheral Artery Disease?


The main peripheral vascular disease causes are listed below:


  • Atherosclerosis,


  • Atherosclerosis, one of the most common causes of PAD, is the buildup of plaque in arteries, which causes them to narrow and reduce blood flow to the lower limbs. 
  • As arteries become less flexible, arterial stiffness increases blood flow restriction and exacerbates PAD even when the patient is at rest.
  • The symptoms and problems of PAD are brought on by both processes, which severely restrict circulation.


  • Arterial Stiffness:


  • Loss of elasticity in the typically flexible artery walls results in arterial stiffness. 
  • This rigidity makes it difficult for blood to circulate freely, affecting circulation even while resting. 
  • Such limited blood flow aggravates diseases such as PAD, exacerbating symptoms and perhaps impairing the patient's general health.

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The causes of PAD include atherosclerosis, which is the primary root cause of peripheral artery disease (PAD). Furthermore, arterial stiffness exacerbates the effects of PAD by impairing blood circulation even while at rest. To improve the quality of life for individuals with PAD, controlling risk factors and implementing therapies are essential for reducing symptoms and averting consequences.

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