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Difference Between Radiotherapy and Chemotherapy: Key Facts

Chemotherapy uses drugs that circulate throughout the body to target cancer cells systemically, while radiotherapy uses high-energy rays to treat specific areas. They differ in action mode, purpose, side effects, and treatment schedules, allowing oncologists to develop personalized treatment plans.

  • 23 Apr 2025
  • 3 min read
  • 3 views

Cancer treatment has transformed significantly over the years, with various options tailored to target different types of cancer. Two of the most common treatments are radiotherapy and chemotherapy. While both aim to destroy cancer cells, they differ significantly in how they work, their side effects, and their application.

This article breaks down the difference between radiotherapy and chemotherapy to better understand how each treatment works.

Chemo vs. radiation: What’s the difference?

Chemotherapy uses drugs, taken orally or intravenously, to kill cancer cells or stop their growth throughout the body, making it effective for metastatic cancer. In contrast, radiotherapy uses high-energy rays to target and destroy cancer cells in an area, making it a localized treatment..

The following are some key chemo and radiation differences:

  1. Mode of action

The biggest difference between radiation and chemo is the mode of action used during treatment. While chemotherapy affects the entire body by circulating through the bloodstream, radiotherapy targets a specific area and does not impact the whole body.

  1. Purpose

Chemotherapy is often used to shrink tumours, prevent cancer from spreading, or eliminate cancer cells that may have spread. Radiotherapy, on the other hand, is used to shrink tumours before surgery, kill the remaining cancer cells after surgery, or provide relief from cancer symptoms.

  1. Side effects

The usual side effects of chemotherapy include hair loss, nausea, fatigue, and a weak immune system. In contrast, radiotherapy has localised side effects like skin irritation or fatigue in the treated area.

  1. Duration and frequency

Chemotherapy may be given in cycles, interspersed with rest periods to allow for recovery. Conversely, radiotherapy is typically administered daily over a set number of weeks.

Conclusion

Understanding the difference between chemotherapy and radiation empowers patients and their families to make well-informed treatment decisions.

It is essential to consult with your healthcare specialist about treatment. Both chemotherapy and radiotherapy, along with other treatments for critical illnesses like cancer, can be expensive. Acquiring a tailored health insurance plan ensures financial protection, helping to cover treatment costs and provide access to the necessary medical care without added financial stress.


Disclaimer: The information provided in this blog is for educational and informational purposes only. It is not intended as a substitute for professional advice, diagnosis, or treatment. Please consult your general physician or another certified medical professional for any questions regarding a medical condition. Relying on any information provided in this blog is solely at your own risk, and ICICI Lombard is not responsible for any effects or consequences resulting from the use of the information shared.

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