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What Are Blood Transfusion Reactions?

Blood transfusion reactions occur when the body responds negatively to transfused blood. These range from mild fever and itching to serious complications like hemolytic reactions that attack red blood cells, febrile reactions from white blood cell sensitivity, allergic responses, delayed reactions causing fatigue and jaundice, and iron overload damaging organs.

  • 25 Apr 2025
  • 3 min read
  • 4 views

A blood transfusion is a life-saving procedure that involves giving blood or blood products. While generally safe, in some cases, the body may react negatively to the new blood resulting in blood transfusion reactions. These blood transfusion reactions can vary from mild to severe, depending on how the immune system responds. While most transfusions are safe, it’s important to be aware of potential risks and symptoms.

 

What are the kinds of reactions that can happen from a blood transfusion?

The most common blood transfusion reactions are mild fevers, itching or rashes. However, more serious transfusion reactions include:

  • A hemolytic reaction where the body attacks transfused red blood cells causing fever, chills, and low blood pressure.
  • A febrile reaction causing mild fever due to white blood cell sensitivity.
  • An allergic reaction causing itching and hives
  • A delayed blood transfusion reaction, usually days or weeks later, when the immune system slowly destroys transfused red blood cells, leading to fatigue and jaundice.
  • An overload of iron resulting in damaged organs.

 

Why awareness matters

Though rare, adverse blood transfusion reactions can be serious. Recognising early symptoms ensures timely medical care. And so, having a health insurance handy, can help cover transfusion-related treatments and unexpected complications, providing financial security.


Disclaimer: The information provided in this blog is for educational and informational purposes only. It is not intended as a substitute for professional advice, diagnosis, or treatment. Please consult your general physician or another certified medical professional for any questions regarding a medical condition. Relying on any information provided in this blog is solely at your own risk, and ICICI Lombard is not responsible for any effects or consequences resulting from the use of the information shared.

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