What are the Causes of Adrenoleukodystrophy?

Adrenoleukodystrophy (ALD) is a genetic disorder passed on from the mother to her child.  This condition arises due to a mutated gene in the X chromosome. As a result, the myelin sheath, which is a membrane that covers the nerve cells gets damaged. This mainly occurs in the brain and spinal cord, and adrenoleukodystrophy is more common in males.

What Are The Causes of Adrenoleukodystrophy?

Causes of adrenoleukodystrophy include mutations in the ABCD-1 gene that produces the ALD protein. ALD is present on the surface of peroxisomes, cell organelle containing enzymes that perform various metabolic functions. It transports very long-chain fatty acids (VLCFAs) into the peroxisome, where they are digested. Dysfunctional ALD protein prevents the breakdown of these acids and leads to their accumulation in the brain, nervous system, and adrenal glands. ALD causes the destruction of the myelin sheath.  It can also be toxic to the blood cells.

Conclusion

Adrenoleukodystrophy affects men more than women because men have just one X chromosome, whereas women have two X chromosomes. There are effective treatments for this condition but are very costly. Having a health insurance plan that covers ALD treatment will help one go for the therapy without having to worry about finances.

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