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Effects of Painkillers Explained

Painkillers may cause liver, kidney, heart, and digestive issues if misused. Understand the risks and consult a doctor before starting any medication.

  • 05 May 2025
  • 3 min read
  • 5 views

Painkillers, often called analgesics, alleviate discomfort caused by injuries, chronic illnesses, and surgeries. Common painkillers include nonsteroidal anti-inflammatory drugs (NSAIDs), acetaminophen, and opioids. Each category has its own set of risks and potential complications. These medications come in over-the-counter tablets, prescription drugs, and intravenous solutions. While they are essential for managing pain and improving quality of life, painkillers are not without risks. 

This article explores the side effects of pain killers to ensure their judicious use.

What are the Side Effects of Pain Killers?

The side effects of pain killers vary based on the type of medication, dosage, and duration of use. The harmful effects of painkillers include:

  1.       Gastrointestinal issues

NSAIDs, such as ibuprofen and aspirin, are commonly used to reduce inflammation and alleviate pain. However, these medications may cause stomach irritation. Prolonged use can lead to gastritis, ulcers, and even gastrointestinal bleeding. Taking these medications with food minimises stomach-related side effects. For individuals who need long-term NSAID use, a doctor might recommend proton pump inhibitors (PPIs) or other drugs to protect the stomach from damage.

  1.       Liver damage

Acetaminophen, often used in muscle pain relief tablets, is safer when consumed in the recommended dosage. However, excessive consumption can cause liver toxicity, which may require medical intervention. The liver processes acetaminophen, and an overdose can overwhelm its detoxification pathways, potentially causing liver toxicity or even failure, which may require a liver transplant in severe cases. Individuals with pre-existing liver conditions, excessive alcohol consumption, or those taking multiple medications should use acetaminophen with extreme caution. It’s crucial to follow dosage instructions and avoid combining acetaminophen with alcohol or other liver-stressing substances.

  1.       Kidney problems

NSAIDs and certain prescription painkillers can impair kidney function, mainly when used over long periods. This risk is higher for those with underlying kidney issues or those who are dehydrated. NSAIDs work by inhibiting certain enzymes that help regulate kidney blood flow, which can result in reduced kidney function over time, leading to kidney damage or even renal failure in extreme cases. This risk is compounded for individuals who have pre-existing kidney conditions, are elderly, or are dehydrated. Staying hydrated and avoiding overuse of painkillers is vital for those at risk. Kidney function should be monitored regularly in long-term users of these medications.

  1.       Cardiovascular risks

Long-term use of NSAIDs has been linked to a greater risk of heart attacks, high blood pressure, and strokes. These medications can elevate blood pressure and cause arterial plaque, narrowing blood vessels and impair circulation. For individuals with pre-existing cardiovascular conditions like hypertension, heart disease, or a history of stroke, it is critical to consult with a doctor before using NSAIDs for pain relief. Alternative medications, such as acetaminophen or topical treatments, may be considered safer options for individuals at risk of cardiovascular events.

Conclusion

While painkillers are effective in providing relief from discomfort, their potential side effects should not be overlooked. Understanding the risks associated with muscle pain relief tablets and other analgesics can help you make safer choices. Always consult your doctor before following any pain management regimen. Additionally, health insurance can provide financial protection during medical complications.


Disclaimer: The information provided in this blog is for educational and informational purposes only. It is not intended as a substitute for professional advice, diagnosis, or treatment. Please consult your general physician or another certified medical professional for any questions regarding a medical condition. Relying on any information provided in this blog is solely at your own risk, and ICICI Lombard is not responsible for any effects or consequences resulting from the use of the information shared.

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