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Causes of Ankylosing Spondylitis

Ankylosing spondylitis is a lifelong inflammatory disease that affects the spine. It is primarily caused by genetic mutations, bacterial infections, and autoimmune responses. Risk factors include age, gender, and family history.

  • 24 Mar 2025
  • 3 min read
  • 21 views

Ankylosing spondylitis (AS) is a rare form of arthritis. It causes extreme pain and spine stiffness. "Ankylosis" translates to “fused bones” or other hard tissue. "Spondylitis" means inflammation occurring in the series of bones that make up your spine (vertebrae). This condition is also called Bechterew disease, and is a lifelong condition. It typically starts in your lower back and can move up to your neck. It can also cause joint damage. Chronic AS can cause you to have a hunch in your spine. Currently, there’s no treatment for AS. But specific medicine and exercise can alleviate pain and strengthen your back. In this article, we’ll look at common ankylosing spondylitis causes.

How is Ankylosing Spondylitis Caused?

Doctors don’t know what causes AS, but it is seen that affected people possess certain factors. The following are the common ankylosing spondylitis causes:

  • HLA-B gene mutation

A majority of the people with AS possess a gene that creates a protein called HLA-B27. Studies show it instructs your immune system to attack bacteria in your body, which then sets off AS symptoms.

  • Bacterial infection

Mutations in the HLA-B27 gene can make a person more prone to a condition of Ankylosing spondylitis which triggers the immune system to attack some common bacteria and sets off symptoms related to Ankylosing spondylitis in the body.

  • HLA-B27 gene inheritance

The reason for getting AS could be the HLA-B27 gene variant inherited from another family member. If a person has AS and tests show that they carry the HLA-B27 gene variant, then there are chances that a person could pass on the gene variant to their offspring who then go on to develop AS.

  • Age

It has seen that people aged between 17 to 45 years are more likely to get AS. and forms of arthritis. Studies say men are more likely to get the disease than women.

  • Autoimmune disease

The chances of developing Ankylosing spondylitis increase if a person has another autoimmune disease, such as psoriasis, Crohn’s disease, or ulcerative colitis.

Conclusion

If you were wondering what the causes of ankylosing spondylitis are, we hope this article has helped. This is a rare disease that does not have a cure. It is vital for individuals with AS to follow the instructions of their medical team in order to manage this condition properly. With proper medication and exercise, one can be relieved from chronic bone and joint pain. Living with AS is not easy, but taking care of your physical and mental health can enhance your daily life. Additionally, having a comprehensive health insurance policy can provide financial support for ongoing treatments, medications, and specialist consultations, ensuring that you receive the best possible care without added financial stress.


Disclaimer: The information provided in this blog is for educational and informational purposes only. It is not intended as a substitute for professional advice, diagnosis or treatment. Please consult a certified medical and/or nutrition professional for any questions. Relying on any information provided in this blog is solely at your own risk, and ICICI Lombard is not responsible for any effects or consequences resulting from the use of the information shared.

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