The pituitary gland in our body releases many kinds of hormones that help in the overall functioning of the body. Adrenocorticotropic hormone (ACTH) is one such chemical messenger secreted by the gland. This has a stimulatory effect on the adrenal gland located above the kidneys. Let’s check the adrenocorticotropic hormone definition and learn about the chemical signaling molecule in detail.
What is Adrenocorticotropic Hormone?
Here we will define adrenocorticotropic hormone, with all its functions.
ACTH is a tropic hormone secreted from the anterior part of the pituitary gland. It stabilizes metabolism and regulates the release of cortisol and androgen from the adrenal glands. The level of ACTH in the body increases during stress and helps manage the condition.
When cortisol levels in the blood are low, the hypothalamus releases a hormone called corticotrophin-releasing hormone (CRH). This signals the pituitary gland to secrete ACTH. When the adrenal glands detect the increased levels of ACTH, they secrete cortisol into the bloodstream. This raises the cortisol level. As its levels rise, it signals the pituitary gland to stop the secretion of ACTH. The adrenocorticotropic hormone levels start to fall, and so does the cortisol concentration.
Abnormal levels of ACTH can indicate underlying diseases. Lower-than-normal concentrations of the hormone in the blood may be due to Addison's disease, pituitary gland disorders, or as a side effect of pituitary surgery or radiation therapy. Abnormally high levels may be due to Cushing’s syndrome.
Conclusion
Any kind of hormonal dysfunction can hamper the body's natural functioning. Those suffering from diseases caused by abnormal hormone levels should visit a doctor immediately and get adequate treatment. A health insurance plan comes in handy in such cases to cover hospitalisation and treatment.
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