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What are the causes of Sjögren's disease?

Sjögren's disease causes involve multiple factors: genetic predisposition making individuals more susceptible though not determining development; viral or bacterial infections potentially triggering abnormal immune responses in genetically vulnerable people; hormonal factors suggested by higher prevalence in women over 40; and connections to other autoimmune disorders like rheumatoid arthritis and lupus indicating shared underlying mechanisms.

  • 28 Apr 2025
  • 3 min read
  • 2 views

Sjögren’s (pronounced as show-grins) disease or syndrome is an autoimmune disorder wherein the body’s immune system mistakenly attacks healthy cells, particularly the moisture-producing glands. This results in dryness of the eyes and mouth. While the exact cause of Sjögren’s disease is not fully known, a combination of genetic, environmental, and immune system factors are believed to contribute to its development. And understanding these causes of Sjögren’s syndrome can help recognise risk factors to seek early medical care.

 

Causes of Sjögren’s disease

The precise causes of Sjögren’s remain unclear, but several factors may trigger the condition:

  • Research suggests that Sjögren’s syndrome may be hereditary, meaning some individuals inherit genes that make them more susceptible. However, genetics alone do not determine whether someone will develop the disease.
  • Certain viral or bacterial infections may activate the immune system abnormally, leading to Sjögren’s syndrome in genetically predisposed individuals.
  • As the disorder is far more common in women, particularly those over 40, research suggests that hormonal changes may play a role.
  • Many people with Sjögren’s syndrome also have other autoimmune disorders such as rheumatoid arthritis or lupus, which suggests a link between these conditions.

 

Managing Sjögren’s disease

Since Sjögren’s disease is chronic, early diagnosis and proper management can help reduce complications. Regular medical care, lifestyle adjustments, and appropriate treatment are essential. Having health insurance can provide financial support, ensuring better management of the condition over time.


Disclaimer: The information provided in this blog is for educational and informational purposes only. It is not intended as a substitute for professional advice, diagnosis, or treatment. Please consult your general physician or another certified medical professional for any questions regarding a medical condition. Relying on any information provided in this blog is solely at your own risk, and ICICI Lombard is not responsible for any effects or consequences resulting from the use of the information shared.

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